Next bus departures

Next departures for Philadelphia to Florence on August 10
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
FlixBus + Greyhound Lines, Inc.	Bus	10:30pm	Philadelphia Bus Station	18h 25m	4:55pm	Bus station	Cheapest
FlixBus + Greyhound Lines, Inc.	Bus	3:05am	Philadelphia Bus Station	13h 50m	4:55pm	Bus station	Fastest
FlixBus + Greyhound Lines, Inc.	Bus	10:00pm	Philadelphia Bus Station	13h 59m	11:59am	Bus station	No tags
	Bus	2:05pm	Camden (Walter Rand Transportation Center)	21h 54m	11:59am	Bus station	No tags

Next departures for Philadelphia to Florence on August 11
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
FlixBus + Greyhound Lines, Inc.	Bus	3:05am	Philadelphia Bus Station	13h 50m	4:55pm	Bus station	Cheapest
	Bus	6:30pm	Philadelphia Bus Station	11h 15m	5:45am	Florence, SC	Fastest
	Bus	12:05am	Philadelphia Bus Station	11h 54m	11:59am	Bus station	No tags
FlixBus + Greyhound Lines, Inc.	Bus	10:00pm	Philadelphia Bus Station	13h 59m	11:59am	Bus station	No tags
FlixBus + Greyhound Lines, Inc.	Bus	10:30pm	Philadelphia Bus Station	18h 25m	4:55pm	Bus station	No tags
	Bus	2:05pm	Camden (Walter Rand Transportation Center)	21h 54m	11:59am	Bus station	No tags

Next departures for Philadelphia to Florence on August 12
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
	Bus	8:05pm	Philadelphia Bus Station	15h 54m	11:59am	Bus station	Cheapest
	Bus	6:30pm	Philadelphia Bus Station	11h 15m	5:45am	Florence, SC	Fastest
	Bus	12:05am	Philadelphia Bus Station	11h 54m	11:59am	Bus station	No tags
FlixBus + Greyhound Lines, Inc.	Bus	3:05am	Philadelphia Bus Station	13h 50m	4:55pm	Bus station	No tags
FlixBus + Greyhound Lines, Inc.	Bus	10:30pm	Philadelphia Bus Station	18h 25m	4:55pm	Bus station	No tags
	Bus	2:05pm	Camden (Walter Rand Transportation Center)	21h 54m	11:59am	Bus station	No tags

Next departures for Philadelphia to Florence on August 13
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
	Bus	12:05am	Philadelphia Bus Station	11h 54m	11:59am	Bus station	Cheapest
	Bus	6:30pm	Philadelphia Bus Station	11h 15m	5:45am	Florence, SC	Fastest
FlixBus + Greyhound Lines, Inc.	Bus	3:05am	Philadelphia Bus Station	13h 50m	4:55pm	Bus station	No tags
	Bus	8:05pm	Philadelphia Bus Station	15h 54m	11:59am	Bus station	No tags
FlixBus + Greyhound Lines, Inc.	Bus	10:30pm	Philadelphia Bus Station	18h 25m	4:55pm	Bus station	No tags
	Bus	2:05pm	Camden (Walter Rand Transportation Center)	21h 54m	11:59am	Bus station	No tags

Next departures for Philadelphia to Florence on August 14
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
FlixBus + Greyhound Lines, Inc.	Bus	3:05am	Philadelphia Bus Station	13h 50m	4:55pm	Bus station	Cheapest
	Bus	6:30pm	Philadelphia Bus Station	11h 15m	5:45am	Florence, SC	Fastest
	Bus	12:05am	Philadelphia Bus Station	11h 54m	11:59am	Bus station	No tags
FlixBus + Greyhound Lines, Inc.	Bus	10:00pm	Philadelphia Bus Station	13h 59m	11:59am	Bus station	No tags
FlixBus + Greyhound Lines, Inc.	Bus	10:30pm	Philadelphia Bus Station	18h 25m	4:55pm	Bus station	No tags
	Bus	2:05pm	Camden (Walter Rand Transportation Center)	21h 54m	11:59am	Bus station	No tags

Next departures for Philadelphia to Florence on August 15
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
FlixBus + Greyhound Lines, Inc.	Bus	3:05am	Philadelphia Bus Station	13h 50m	4:55pm	Bus station	Cheapest
	Bus	6:30pm	Philadelphia Bus Station	11h 15m	5:45am	Florence, SC	Fastest
	Bus	12:05am	Philadelphia Bus Station	11h 54m	11:59am	Bus station	No tags
FlixBus + Greyhound Lines, Inc.	Bus	10:00pm	Philadelphia Bus Station	13h 59m	11:59am	Bus station	No tags
FlixBus + Greyhound Lines, Inc.	Bus	10:30pm	Philadelphia Bus Station	18h 25m	4:55pm	Bus station	No tags
	Bus	2:05pm	Camden (Walter Rand Transportation Center)	21h 54m	11:59am	Bus station	No tags

Last refresh of the prices: Yesterday at 2:15 PM EDT.

Compare 2 ways to go from Philadelphia to Florence

We recommend taking the train

Among the sustainable travel choices, the Train stands out as a good way to reach Florence. The journey takes about 10 hours 55 minutes, and with fares starting at just $137, it presents an excellent value for a comfortable ride.

3train per day

10h 55mAverage Duration

758 kmDistance

69kgCO₂ emissions

	Average Price	Average Duration	CO₂ emissions	Actions
Bus	Average Price$85 - $404	Average Duration13h 59m	CO₂ emissions 19kg CO₂e
Train	Average Price$137 - $617	Average Duration10h 55m	CO₂ emissions 69kg CO₂e

Bus stations and stops in Philadelphia and Florence

Stops in Philadelphia

A
Bus Station
1001 Filbert St, Philadelphia, PA 19107, USA
B
Philadelphia Airport
Visit page
C
#2842 St.Vincent St
15th St Trolley Station, Philadelphia, PA 19102, USA
D
Island Av & Suffolk Av MBFS
3000 Island Ave, Philadelphia, PA 19153, USA
E
Independence Travel Center
Off of Race Street between 5th Street and, N 6th St, Philadelphia, PA 19106, USA
Visit page
F
NRG SEPTA Station
3701 Broad St, Philadelphia, PA 19148, USA

Stops in Florence

A
Florence Bus Station
619 S Irby St, Florence, SC 29501, USA
Visit page
B
TA Travel Center - Florence
2301 W Lucas St, Florence, SC 29501, USA

Compare bus companies

Greyhound

3.5/588,040 reviews

Staff3.6

Timeliness3.0

Cleanliness3.4

Wi‑Fi2.5

FlixBus

3.5/515,055 reviews

Staff4.1

Timeliness4.0

Cleanliness4.1

Wi‑Fi2.7

US bus companies:FlixBus, Greyhound, Futura, Elite, Chihuahuenses, Tufesa, Adirondack Trailways

Frequently asked questions about travelling from Philadelphia, PA, US to Florence, SC, US by bus

Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.

How much is the bus ticket from Philadelphia to Florence?
The cheapest bus tickets from Philadelphia to Florence start from $85. The average price for this route is around $130. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from Philadelphia to Florence?
The average bus travel time from Philadelphia to Florence is 13h 59m, covering a distance of 761 km. The quickest bus can get you there in 11h 15m and is operated by FlixBus.
Which bus companies service the Philadelphia to Florence route?
Several major bus companies operate on this route with 6 buses available per day, including services from Greyhound, FlixBus.
What are the earliest and latest departure times for the bus from Philadelphia to Florence?
The earliest bus departs from Philadelphia to Florence at 12:05am. And the latest bus departs at 10:30pm.
What are the CO₂ emissions for the bus trip from Philadelphia to Florence?
A bus trip from Philadelphia to Florence generates an estimated 19.003974999999997 kg of CO₂, making it a highly eco-friendly travel option and a mode of travel recommended by Busbud.
What is the best bus company from Philadelphia to Florence?
According to Busbud customers, the highest-rated bus company on this route is Greyhound, with an average rating of 3.5 out of 5 stars based on 88023 reviews.
Which bus company has the best Wi-Fi from Philadelphia to Florence?
Based on Busbud reviews, the bus company FlixBus has the highest Wi-Fi rating with a score of 2.7.
Which bus company has the best on-time performance from Philadelphia to Florence?
According to Busbud traveller reviews, the most punctual bus company on this route is FlixBus, with a punctuality rating of 4.0 out of 5 stars.
Which bus company has the cleanest buses from Philadelphia to Florence?
According to Busbud traveller reviews, the bus company with the cleanest buses on this route is FlixBus, with a cleanliness rating of 4.1 out of 5 stars.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found

08-07

$247

08-08

$104

Today

$239

08-10

$188

08-11

$168

08-12

$130

08-13

$160

08-14

$175

The cheapest trip from Philadelphia, PA, US to Florence, SC, US was searched and found on Aug 8, 2026 with a price of $104

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Philadelphia, PA, US to Florence, SC, US, as early as possible.

You can expect to pay from $104 to $289 for a bus ticket from Philadelphia, PA, US to Florence, SC, US based on the last 2 days. You can expect to find the cheapest price for the trip at $130 which is on 2026-08-12.

Usually FlixBus will charge you higher prices for tickets closer to the departure date. To find the best prices, you should be flexible on your date of travel.