Next bus departures

Next departures for Syracuse to Chicago on August 1
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
	Bus	4:30am	Syracuse (Regional Transportation Center)	16h 35m	8:05pm	Downtown Greyhound Station	Cheapest
	Bus	7:35pm	Syracuse (Regional Transportation Center)	15h 25m	10:00am	Downtown Greyhound Station	Fastest
	Bus	4:30am	Syracuse (Regional Transportation Center)	1d 4h	8:00am	537-517 W. Jackson Blvd	No tags
Greyhound Lines, Inc. + FlixBus	Bus	7:35pm	Syracuse (Regional Transportation Center)	18h 50m	1:25pm	Chicago 95Th & Dan Ryan	No tags
	Bus	4:30am	Syracuse (Regional Transportation Center)	20h 5m	11:35pm	Chicago 95Th & Dan Ryan	No tags

Next departures for Syracuse to Chicago on August 3
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
	Bus	7:35pm	Syracuse (Regional Transportation Center)	15h 25m	10:00am	Downtown Greyhound Station	CheapestFastest
	Bus	4:30am	Syracuse (Regional Transportation Center)	16h 35m	8:05pm	Downtown Greyhound Station	No tags
Greyhound Lines, Inc. + FlixBus	Bus	7:35pm	Syracuse (Regional Transportation Center)	18h 50m	1:25pm	Chicago 95Th & Dan Ryan	No tags
	Bus	4:30am	Syracuse (Regional Transportation Center)	1d 4h	8:00am	537-517 W. Jackson Blvd	No tags
	Bus	4:30am	Syracuse (Regional Transportation Center)	20h 5m	11:35pm	Chicago 95Th & Dan Ryan	No tags

Next departures for Syracuse to Chicago on August 4
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
	Bus	4:30am	Syracuse (Regional Transportation Center)	16h 35m	8:05pm	Downtown Greyhound Station	Cheapest
	Bus	7:35pm	Syracuse (Regional Transportation Center)	15h 25m	10:00am	Downtown Greyhound Station	Fastest
	Bus	4:30am	Syracuse (Regional Transportation Center)	1d 4h	8:00am	537-517 W. Jackson Blvd	No tags
Greyhound Lines, Inc. + FlixBus	Bus	7:35pm	Syracuse (Regional Transportation Center)	22h 25m	5:00pm	Chicago 95Th & Dan Ryan	No tags
	Bus	4:30am	Syracuse (Regional Transportation Center)	20h 5m	11:35pm	Chicago 95Th & Dan Ryan	No tags

Next departures for Syracuse to Chicago on August 5
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
	Bus	4:30am	Syracuse (Regional Transportation Center)	16h 35m	8:05pm	Downtown Greyhound Station	Cheapest
	Bus	7:35pm	Syracuse (Regional Transportation Center)	15h 25m	10:00am	Downtown Greyhound Station	Fastest
	Bus	4:30am	Syracuse (Regional Transportation Center)	1d 4h	8:00am	537-517 W. Jackson Blvd	No tags
Greyhound Lines, Inc. + FlixBus	Bus	7:35pm	Syracuse (Regional Transportation Center)	18h 50m	1:25pm	Chicago 95Th & Dan Ryan	No tags
	Bus	4:30am	Syracuse (Regional Transportation Center)	20h 5m	11:35pm	Chicago 95Th & Dan Ryan	No tags

Next departures for Syracuse to Chicago on August 6
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
Greyhound Lines, Inc. + FlixBus	Bus	7:35pm	Syracuse (Regional Transportation Center)	18h 50m	1:25pm	Chicago 95Th & Dan Ryan	Cheapest
	Bus	7:35pm	Syracuse (Regional Transportation Center)	15h 25m	10:00am	Downtown Greyhound Station	Fastest
	Bus	4:30am	Syracuse (Regional Transportation Center)	16h 35m	8:05pm	Downtown Greyhound Station	No tags
	Bus	4:30am	Syracuse (Regional Transportation Center)	1d 4h	8:00am	537-517 W. Jackson Blvd	No tags
	Bus	4:30am	Syracuse (Regional Transportation Center)	20h 5m	11:35pm	Chicago 95Th & Dan Ryan	No tags

Next departures for Syracuse to Chicago on August 7
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
	Bus	4:30am	Syracuse (Regional Transportation Center)	20h 5m	11:35pm	Chicago 95Th & Dan Ryan	Cheapest
	Bus	7:35pm	Syracuse (Regional Transportation Center)	15h 25m	10:00am	Downtown Greyhound Station	Fastest
	Bus	4:30am	Syracuse (Regional Transportation Center)	16h 35m	8:05pm	Downtown Greyhound Station	No tags
Greyhound Lines, Inc. + FlixBus	Bus	7:35pm	Syracuse (Regional Transportation Center)	18h 50m	1:25pm	Chicago 95Th & Dan Ryan	No tags
	Bus	4:30am	Syracuse (Regional Transportation Center)	1d 4h	8:00am	537-517 W. Jackson Blvd	No tags

Last refresh of the prices: Today at 2:42 PM EDT.

Compare 2 ways to go from Syracuse to Chicago

We recommend taking the train

Among the sustainable travel choices, the Train stands out as a good way to reach Chicago. The journey takes about 13 hours 7 minutes, and with fares starting at just COP 227,665, it presents an excellent value for a comfortable ride.

1train per day

13h 7mAverage Duration

950 kmDistance

86kgCO₂ emissions

	Average Price	Average Duration	CO₂ emissions	Actions
Bus	Average PriceCOP 218,315 - COP 857,422	Average Duration18h 50m	CO₂ emissions 24kg CO₂e
Train	Average PriceCOP 227,665 - COP 2,758,778	Average Duration13h 7m	CO₂ emissions 86kg CO₂e

Bus stations and stops in Syracuse and Chicago

Stops in Syracuse

A
Regional Transportation Center
1 Walsh Circle Ste 30, Syracuse, NY 13208
B
Syracuse Airport
Visit page
C
Syracuse University
Bus stops at Schine Student Center across the street from the Sheraton Parking Garage., Schine Student Center, 303 University Pl, Syracuse, NY 13210
Visit page
D
Syracuse University - Lyman Hall
College Place, Syracuse, NY 13210, USA
E
New York State Fairgrounds
581 State Fair Blvd, Syracuse, NY 13209, USA
F
Syracuse, NY
349-399 US-11, Syracuse, NY 13202, USA

Stops in Chicago

A
Downtown Greyhound Station
630 W Harrison St, Chicago, IL 60607, USA
Visit page
B
Chicago O'Hare International Airport
Visit page
C
Polk St & Canal St
500-536 W Polk St, Chicago IL 60607, USA
D
Tornado Bus S Kedzie Ave
2807 S Kedzie Ave, Chicago, IL 60623, USA
E
Cumberland CTA
5800 N Cumberland Ave, Chicago, IL 60631, USA
F
Turimex California Ave
2139 S California Ave, Chicago, IL 60608, USA

Compare bus companies

Greyhound

3.5/587,589 reviews

Staff3.6

Timeliness2.9

Cleanliness3.4

Wi‑Fi2.5

FlixBus

3.5/513,117 reviews

Staff4.2

Timeliness4.0

Cleanliness4.1

Wi‑Fi2.7

US bus companies:FlixBus, Greyhound, Futura, Elite, Chihuahuenses, Tufesa, Adirondack Trailways

Frequently asked questions about travelling from Syracuse, US to Chicago by bus

Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.

How much is the bus ticket from Syracuse to Chicago?
The cheapest bus tickets from Syracuse to Chicago start from COP 218,315. The average price for this route is around COP 286,656. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from Syracuse to Chicago?
The average bus travel time from Syracuse to Chicago is 18h 50m, covering a distance of 951 km. The quickest bus can get you there in 15h 25m and is operated by Greyhound.
Which bus companies service the Syracuse to Chicago route?
Several major bus companies operate on this route with 5 buses available per day, including services from Greyhound, FlixBus.
What are the earliest and latest departure times for the bus from Syracuse to Chicago?
The earliest bus departs from Syracuse to Chicago at 3:20am. And the latest bus departs at 7:35pm.
What are the CO₂ emissions for the bus trip from Syracuse to Chicago?
A bus trip from Syracuse to Chicago generates an estimated 23.767375 kg of CO₂, making it a highly eco-friendly travel option and a mode of travel recommended by Busbud.
What is the best bus company from Syracuse to Chicago?
According to Busbud customers, the highest-rated bus company on this route is Greyhound, with an average rating of 3.5 out of 5 stars based on 87588 reviews.
Which bus company has the best Wi-Fi from Syracuse to Chicago?
Based on Busbud reviews, the bus company FlixBus has the highest Wi-Fi rating with a score of 2.7.
Which bus company has the best on-time performance from Syracuse to Chicago?
According to Busbud traveller reviews, the most punctual bus company on this route is FlixBus, with a punctuality rating of 4.0 out of 5 stars.
Which bus company has the cleanest buses from Syracuse to Chicago?
According to Busbud traveller reviews, the bus company with the cleanest buses on this route is FlixBus, with a cleanliness rating of 4.1 out of 5 stars.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found

07-29

COP 648,679

07-30

COP 683,661

Today

COP 655,008

08-01

COP 476,922

08-02

COP 270,214

08-03

COP 511,935

08-04

COP 348,127

08-05

COP 317,916

The cheapest trip from Syracuse, US to Chicago was searched and found on Aug 2, 2026 with a price of COP 270,214

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Syracuse, US to Chicago, as early as possible.

You can expect to pay from COP 270,214 to COP 1,155,812 for a bus ticket from Syracuse, US to Chicago based on the last 2 days. You can expect to find the cheapest price for the trip at COP 270,214 which is on 2026-08-02.