Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Bus | Florence, SC | Jacksonville Bus Station | CheapestFastest | ||||
Greyhound Lines, Inc. + FlixBus | Bus | Bus station | Jacksonville Bus Station | No tags | ||||
Greyhound Lines, Inc. + FlixBus | Bus | Bus station | Jacksonville Bus Station | No tags |
Last refresh of the prices: Today at 9:57 AM EDT.
Compare 2 ways to go from Florence to Jacksonville
Among the sustainable travel choices, the Train stands out as a good way to reach Jacksonville. The journey takes about 6 hours 6 minutes and with fares starting at just CLP 59,175, it presents an excellent value for a comfortable ride.
Bus stations and stops in Florence and Jacksonville
Stops in Florence
- A
Florence Bus Station
619 S Irby St, Florence, SC 29501, USA - B
TA Travel Center - Florence
2301 W Lucas St, Florence, SC 29501, USA
Stops in Jacksonville
- A
Jacksonville Amtrak Station
3570 Clifford Ln, Jacksonville, FL 32209, USA - B
W Forsyth St
1111 W Forsyth St, Jacksonville, FL 32204, USA - C
Kings Avenue Station
1003 Kings Avenue, Jacksonville, FL 32207 - D
JRTC Greyhound Bus Station
111 W. Forsyth St, Jacksonville, FL 32202, USA
Compare bus companies
Frequently asked questions about traveling from Florence, SC, US to Jacksonville, FL by bus
Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.
How much is the bus ticket from Florence to Jacksonville?
The cheapest bus tickets from Florence to Jacksonville start from CLP 44,809. The average price for this route is around CLP 83,755. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from Florence to Jacksonville?
The average bus trip duration from Florence to Jacksonville is 14h 50m, covering a distance of 289 miles (466 km). The quickest bus can get you there in 5h 10m and is operated by FlixBus.
Which bus companies service the Florence to Jacksonville route?
What is the earliest and latest departure time for the bus from Florence to Jacksonville?
The earliest bus departs from Florence to Jacksonville at 5:45am. And the latest bus departs at 4:15pm.
What are the CO₂ emissions for the bus trip from Florence to Jacksonville?
A bus trip from Florence to Jacksonville generates an estimated 11.6295 kg of CO₂, making it a highly eco-friendly travel option and recommended mode of travel by Busbud.
What is the best bus company from Florence to Jacksonville?
According to Busbud customers, the highest-rated bus company on this route is FlixBus, with an average rating of 3.5 out of 5 stars based on 13093 reviews.
Which bus company has the best Wi-Fi from Florence to Jacksonville?
Based on reviews on Busbud, the bus company FlixBus has the best Wi-Fi rating with a score of 2.7.
Which bus company has the most timely service from Florence to Jacksonville?
According to Busbud traveler reviews, the most timely bus company on this route is FlixBus, with a punctuality rating of 4.0 out of 5 stars.
Which bus company has the cleanest buses from Florence to Jacksonville?
According to Busbud traveler reviews, the bus company with the cleanest buses on this route is FlixBus, with a cleanliness rating of 4.1 out of 5 stars.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Florence, SC, US to Jacksonville, FL was searched and found on Jul 29, 2026 with a price of CLP 37,996To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Florence, SC, US to Jacksonville, FL, as early as possible.
You can expect to pay from CLP 37,996 to CLP 89,304 for a bus ticket from Florence, SC, US to Jacksonville, FL based on the last 2 days. You can expect to find the cheapest price for the trip at CLP 45,597 which is on 2026-08-03.
