Previously seen trips
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Price and booking link |
|---|---|---|---|---|---|---|---|
Greyhound + FlixBus | Bus | Florence, SC | Manchester | ||||
FlixBus + Greyhound | Bus | Florence, SC | Manchester | ||||
FlixBus + Greyhound | Bus | Florence, SC | Manchester | ||||
 | Bus | Bus station | Manchester | ||||
| Bus | Bus station | Manchester |
Get from Florence to Manchester
The journey takes about 13 hours 4 minutes and with fares starting at just PEN 249, it presents an excellent value for a comfortable ride.
Compare bus companies
Greyhound Lines offers the most comprehensive intercity bus services in the United States. They operate a modern, environmentally friendly fleet that serves more than 2400 destinations and carries nearly 16 million passengers annually. When traveling with them, you can expect free WiFi, onboard entertainment, bathrooms, power outlets and decent legroom. One of the great perks of Greyhound is that they connect big cities and smaller towns in the US, where you usually can't get to by train or plane. If you're looking for safe and affordable transportation, Greyhound is a great choice.
Frequently asked questions about traveling from Florence, SC, US to Manchester, TN, US by bus
Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.
How much is the bus ticket from Florence to Manchester?
The cheapest bus tickets from Florence to Manchester start from PEN 249. The average price for this route is around PEN 279. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from Florence to Manchester?
The average bus trip duration from Florence to Manchester is 13h 4m, covering a distance of 369 miles (595 km). The quickest bus can get you there in 11h 35m and is operated by Greyhound.
Which bus companies service the Florence to Manchester route?
Several major bus companies operate on this route with 2 buses available per day.
What is the earliest and latest departure time for the bus from Florence to Manchester?
The earliest bus departs from Florence to Manchester at 5:45am. And the latest bus departs at 4:15pm.
What are the CO₂ emissions for the bus trip from Florence to Manchester?
A bus trip from Florence to Manchester generates an estimated 14.87015 kg of CO₂, making it a highly eco-friendly travel option and recommended mode of travel by Busbud.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Florence, SC, US to Manchester, TN, US was searched and found on Jul 20, 2026 with a price of PEN 224To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Florence, SC, US to Manchester, TN, US, as early as possible.
You can expect to pay from PEN 224 to PEN 254 for a bus ticket from Florence, SC, US to Manchester, TN, US based on the last 2 days. You can expect to find the cheapest price for the trip at PEN 224 which is on 2026-07-20.
