Next available departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
Greyhound Lines, Inc. + FlixBus | Frederick | Florence, SC | Cheapest | |||||
 | Frederick | Bus station | Fastest | |||||
 | Frederick | Florence Station | No tags | |||||
Greyhound Lines, Inc. + FlixBus | Frederick | Florence, SC | No tags | |||||
| Frederick | Florence Station | No tags | |||||
| Frederick (Airport), MD | Florence Station | No tags | |||||
| Frederick (Airport), MD | Florence Station | No tags |
Last refresh of the prices: Last Sunday at 11:31 PM EDT.
Get from Frederick to Florence
The journey takes about 19 hours 20 minutes and with fares starting at just COP 303,245, it presents an excellent value for a comfortable ride.
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Frequently asked questions about traveling from Frederick to Florence, SC, US by bus
Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.
How much is the bus ticket from Frederick to Florence?
The cheapest bus tickets from Frederick to Florence start from COP 303,245. The average price for this route is around COP 331,702. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from Frederick to Florence?
The average bus trip duration from Frederick to Florence is 19h 20m, covering a distance of 383 miles (618 km). The quickest bus can get you there in 12h 19m and is operated by Greyhound.
Which bus companies service the Frederick to Florence route?
What is the earliest and latest departure time for the bus from Frederick to Florence?
The earliest bus departs from Frederick to Florence at 10:25am. And the latest bus departs at 11:40pm.
What are the CO₂ emissions for the bus trip from Frederick to Florence?
A bus trip from Frederick to Florence generates an estimated 15.427975 kg of CO₂, making it a highly eco-friendly travel option and recommended mode of travel by Busbud.
What is the best bus company from Frederick to Florence?
According to Busbud customers, the highest-rated bus company on this route is Amtrak, with an average rating of 4.1 out of 5 stars based on 6437 reviews.
Which bus company has the best Wi-Fi from Frederick to Florence?
Based on reviews on Busbud, the bus company Amtrak has the best Wi-Fi rating with a score of 3.6.
Which bus company has the most timely service from Frederick to Florence?
According to Busbud traveler reviews, the most timely bus company on this route is Amtrak, with a punctuality rating of 3.8 out of 5 stars.
Which bus company has the cleanest buses from Frederick to Florence?
According to Busbud traveler reviews, the bus company with the cleanest buses on this route is Amtrak, with a cleanliness rating of 4.5 out of 5 stars.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Frederick to Florence, SC, US was searched and found on Aug 21, 2026 with a price of COP 304,349To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Frederick to Florence, SC, US, as early as possible.
You can expect to pay from COP 304,349 to COP 804,488 for a bus ticket from Frederick to Florence, SC, US based on the last 2 days. You can expect to find the cheapest price for the trip at COP 304,349 which is on 2026-08-21.
