Previously seen trips
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Price and booking link |
|---|---|---|---|---|---|---|---|
 | Bus | Downtown Transit Center | Florence, SC | ||||
FlixBus + Greyhound | Bus | Indianapolis Bus Station | Bus station | ||||
Greyhound + FlixBus | Bus | Indianapolis Bus Station | Bus station | ||||
FlixBus + Greyhound | Bus | Indianapolis Bus Station | Florence, SC | ||||
FlixBus + Greyhound | Bus | Indianapolis Bus Station | Florence, SC |
Get from Indianapolis to Florence
The journey takes about 1 day, 1 hour 5 minutes and with fares starting at just $90, it presents an excellent value for a comfortable ride.
Where are the popular stops in Indianapolis and Florence?
Stops in Florence
- A
Florence Bus Station
619 S Irby St, Florence, SC 29501, USA - B
TA Travel Center - Florence
2301 W Lucas St, Florence, SC 29501, USA
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Frequently asked questions about traveling from Indianapolis to Florence, SC, US by bus
Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.
How much is the bus ticket from Indianapolis to Florence?
The cheapest bus tickets from Indianapolis to Florence start from $90. The average price for this route is around $105. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from Indianapolis to Florence?
The average bus trip duration from Indianapolis to Florence is 1d 1h, covering a distance of 521 miles (841 km). The quickest bus can get you there in 20h 10m and is operated by Greyhound.
Which bus companies service the Indianapolis to Florence route?
What is the earliest and latest departure time for the bus from Indianapolis to Florence?
The earliest bus departs from Indianapolis to Florence at 12:15am. And the latest bus departs at 11:30pm.
What are the CO₂ emissions for the bus trip from Indianapolis to Florence?
A bus trip from Indianapolis to Florence generates an estimated 21.001075 kg of CO₂, making it a highly eco-friendly travel option and recommended mode of travel by Busbud.
What is the best bus company from Indianapolis to Florence?
According to Busbud customers, the highest-rated bus company on this route is Amtrak, with an average rating of 4.1 out of 5 stars based on 5817 reviews.
Which bus company has the best Wi-Fi from Indianapolis to Florence?
Based on reviews on Busbud, the bus company Amtrak has the best Wi-Fi rating with a score of 3.6.
Which bus company has the most timely service from Indianapolis to Florence?
According to Busbud traveler reviews, the most timely bus company on this route is FlixBus, with a punctuality rating of 4.0 out of 5 stars.
Which bus company has the cleanest buses from Indianapolis to Florence?
According to Busbud traveler reviews, the bus company with the cleanest buses on this route is Amtrak, with a cleanliness rating of 4.5 out of 5 stars.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Indianapolis to Florence, SC, US was searched and found on Jun 16, 2026 with a price of $86To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Indianapolis to Florence, SC, US, as early as possible.
You can expect to pay from $86 to $125 for a bus ticket from Indianapolis to Florence, SC, US based on the last 2 days. You can expect to find the cheapest price for the trip at $97 which is on 2026-06-20.
Usually FlixBus will charge you higher prices for tickets closer to the departure date. To find the best prices, you should be flexible on your date of travel.
