Next available departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Rome Tiburtina Bus Station | Isernia | Cheapest | |||||
 | Termini | Isernia | Fastest | |||||
| Rome Fiumicino Airport | Isernia | No tags | |||||
| Aeroporto Ciampino Airport (CIA) | Isernia | No tags |
Last refresh of the prices: Today at 3:19 PM CEST.
Compare 2 ways to go from Rome to Isernia
Among the sustainable travel choices, the Train stands out as a good way to reach Isernia. The journey takes about 2 hours 8 minutes and with fares starting at just MAD 198, it presents an excellent value for a comfortable ride.
Where are the popular stops in Rome and Isernia?
Stops in Rome
- APiazza dei Cinquecento 1, 00185 Roma RM, Italy
- BLargo Guido Mazzoni, 3, 00162 Roma, Italy
- C
Rome Fiumicino Airport (FCO), Train station
Fiumicino Aeroporto, 00054 Fiumicino RM, Italy - DRoma S.Pietro, 00165 Roma RM, Italy
- ERoma Trastevere Railway Station, 00152 Roma RM, Italy
- FCesano Di Roma, 00123 Roma RM, Italy
Compare companies
Frequently asked questions about traveling from Rome to Isernia by bus or train
Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.
How much is a ticket from Rome to Isernia?
The cheapest tickets from Rome to Isernia start from MAD 114. The average price for this route is around MAD 240. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the ride from Rome to Isernia?
The average trip duration from Rome to Isernia is 4h 36m, covering a distance of 94 miles (151 km). The quickest vehicle can get you there in 2h 8m and is operated by Trenitalia.
Which companies service the Rome to Isernia route?
Several major companies operate on this route with 2 trips available per day, including services from FlixBus, Trenitalia.
What is the earliest and latest departure time from Rome to Isernia?
The earliest trip departs from Rome to Isernia at 4:05am. And the latest trip departs at 11:55pm.
What are the CO₂ emissions for the trip from Rome to Isernia?
A trip from Rome to Isernia generates an estimated 3.759175 kg of CO₂, making it a highly eco-friendly travel option and recommended mode of travel by Busbud.
What is the best company from Rome to Isernia?
According to Busbud customers, the highest-rated company on this route is Trenitalia, with an average rating of 3.9 out of 5 stars based on 58 reviews.
Which company has the best Wi-Fi from Rome to Isernia?
Based on reviews on Busbud, the company FlixBus has the best Wi-Fi rating with a score of 2.7.
Which company has the most timely service from Rome to Isernia?
According to Busbud traveler reviews, the most timely company on this route is Trenitalia, with a punctuality rating of 4.6 out of 5 stars.
Which company has the cleanest vehicles from Rome to Isernia?
According to Busbud traveler reviews, the company with the cleanest vehicles on this route is Trenitalia, with a cleanliness rating of 4.7 out of 5 stars.
Find cheapest prices for buses and trains
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Rome to Isernia was searched and found on Apr 21, 2026 with a price of MAD 120To save money and be sure you have the best seat, it's a good idea to buy your bus and train tickets from Rome to Isernia, as early as possible.
You can expect to pay from MAD 120 to MAD 548 for a bus or train ticket from Rome to Isernia based on the last 2 days. You can expect to find the cheapest price for the trip at MAD 120 which is on 2026-04-21.
