Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Bus | Brussels South (Gare du Midi) | Florenc | CheapestFastest |
Last refresh of the prices: Yesterday at 10:03 PM CEST.
Compare 2 ways to go from Brussels to Prague
Among the sustainable travel choices, the Bus stands out as a good way to reach Prague. The journey takes about 18 hours 35 minutes, and with fares starting at just NZ$59, it presents an excellent value for a comfortable ride.
Bus stations and stops in Brussels and Prague
Stops in Brussels
- A
Brussels South (Gare du Midi)
Rue de France 85, 1060 Saint-Gilles, Belgium - B
Brux-Nord
Boulevard Simon Bolivar 7, 1030 Schaerbeek, Belgium - C
Centrale
Rue de Loxum 5, 1000 Bruxelles, Belgium - D
Congrès
Pachecolaan 5, 1000 Brussel, Belgium
Stops in Prague
- A
Černý Most
Chlumecká, 198 00 Praha 20, Czech Republic - B
Zličín
Drahoňovského, 163 00 Praha 17, Czech Republic - C
PRG Airport
Aviatická, 161 08, Praha 6, Czechia - D
Florenc
Křižíkova 2b, Nové Město, 186 00 Praha-Praha 8, Czech Republic - E
Tomíčkova
Tomíčkova 2234, Chodov, 148 00 Praha-Praha 11, Czechia - F
Hlavní nádraží
300/8 Wilsonova, 110 00 Praha, Czechia
Compare companies
Frequently asked questions about travelling from Brussels to Prague by bus
Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.
How much is the bus ticket from Brussels to Prague?
The cheapest bus tickets from Brussels to Prague start from NZ$59. The average price for this route is around NZ$177. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from Brussels to Prague?
The average bus travel time from Brussels to Prague is 18h 35m, covering a distance of 713 km. The quickest bus can get you there in 11h 55m and is operated by RegioJet.
Which bus companies service the Brussels to Prague route?
Several major bus companies operate on this route with 51 buses available per day, including services from FlixBus, BlaBlaCar Bus, RegioJet, Musil Tour.
What are the earliest and latest departure times for the bus from Brussels to Prague?
The earliest bus departs from Brussels to Prague at 12:45am. And the latest bus departs at 10:55pm.
What are the CO₂ emissions for the bus trip from Brussels to Prague?
A bus trip from Brussels to Prague generates an estimated 17.811275000000002 kg of CO₂, making it a highly eco-friendly travel option and a mode of travel recommended by Busbud.
What is the best bus company from Brussels to Prague?
According to Busbud customers, the highest-rated bus company on this route is RegioJet, with an average rating of 4.1 out of 5 stars based on 1102 reviews.
Which bus company has the best Wi-Fi from Brussels to Prague?
Based on Busbud reviews, the bus company RegioJet has the highest Wi-Fi rating with a score of 3.8.
Which bus company has the best on-time performance from Brussels to Prague?
According to Busbud traveller reviews, the most punctual bus company on this route is RegioJet, with a punctuality rating of 4.1 out of 5 stars.
Which bus company has the cleanest buses from Brussels to Prague?
According to Busbud traveller reviews, the bus company with the cleanest buses on this route is RegioJet, with a cleanliness rating of 4.4 out of 5 stars.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Brussels to Prague was searched and found on Aug 13, 2026 with a price of NZ$124To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Brussels to Prague, as early as possible.
You can expect to pay from NZ$124 to NZ$378 for a bus ticket from Brussels to Prague based on the last 2 days. You can expect to find the cheapest price for the trip at NZ$124 which is on 2026-08-13.
