Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Bus
| Mainz | PRG Airport | Cheapest | ||||
| Bus
| Mainz | Prague (Central Bus Station Florenc) | Fastest | ||||
| Bus
| Mainz | PRG Airport | No tags |
Last refresh of the prices: Yesterday at 3:25 PM CEST.
Compare 2 ways to go from Mainz to Prague
Among the sustainable travel choices, the Bus stands out as a good way to reach Prague. The journey takes about 11 hours 40 minutes, and with fares starting at just PEN 140, it presents an excellent value for a comfortable ride.
Bus stations and stops in Mainz and Prague
Stops in Mainz
- A
Mainz
Hechtsheimer Str. 65, 55131 Mainz, Germany - B
Mainz- Kaiser-Wilhelm-Ring 16- gegenüberliegende Straßenseite
Kaiser-Wilhelm-Ring 16 (gegenüberliegende Straßenseite), 55118 Mainz
Stops in Prague
- A
PRG Airport
Aviatická, 161 08, Praha 6, Czechia - B
Černý Most
Chlumecká, 198 00 Praha 20, Czech Republic - C
Florenc
Křižíkova 2b, Nové Město, 186 00 Praha-Praha 8, Czech Republic - D
Tomíčkova
Tomíčkova 2234, Chodov, 148 00 Praha-Praha 11, Czechia - E
Zličín
Drahoňovského, 163 00 Praha 17, Czech Republic - F
Hlavní nádraží
300/8 Wilsonova, 110 00 Praha, Czechia
Compare bus companies
Based on 16015 reviews, the company was rated 3.5 stars on Busbud. Travellers were especially satisfied with the ticket access and the temperature but often complained with the Wi‑Fi. FlixBus ticket prices on this trip start at PEN 140
Frequently asked questions about travelling from Mainz to Prague by bus
Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.
How much is the bus ticket from Mainz to Prague?
The cheapest bus tickets from Mainz to Prague start from PEN 140. The average price for this route is around PEN 193. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from Mainz to Prague?
The average bus travel time from Mainz to Prague is 11h 40m, covering a distance of 436 km. The quickest bus can get you there in 8h 10m and is operated by FlixBus.
Which bus companies service the Mainz to Prague route?
Several major bus companies operate on this route with 5 buses available per day.
What are the earliest and latest departure times for the bus from Mainz to Prague?
The earliest bus departs from Mainz to Prague at 4:20pm. And the latest bus departs at 10:30pm.
What are the CO₂ emissions for the bus trip from Mainz to Prague?
A bus trip from Mainz to Prague generates an estimated 10.897225 kg of CO₂, making it a highly eco-friendly travel option and a mode of travel recommended by Busbud.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Mainz to Prague was searched and found on Oct 5, 2026 with a price of PEN 125To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Mainz to Prague, as early as possible.
You can expect to pay from PEN 125 to PEN 475 for a bus ticket from Mainz to Prague based on the last 2 days. You can expect to find the cheapest price for the trip at PEN 125 which is on 2026-10-05.
What's the cheapest way to go from Mainz to Prague?
The Bus is the cheapest travel choice for this destination
