Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Bus | Aeroporto Ciampino Airport (CIA) | Prague (Central Bus Station Florenc) | Cheapest | ||||
| Bus | Rome Tiburtina Bus Station | Prague (Main Railway Station) | Fastest | ||||
| Bus | Aeroporto Ciampino Airport (CIA) | PRG Airport | No tags | ||||
| Bus | Rome Tiburtina Bus Station | PRG Airport | No tags | ||||
| Bus | Rome Tiburtina Bus Station | PRG Airport | No tags |
Last refresh of the prices: Yesterday at 23:48 CEST.
Get from Rome to Prague
The journey takes about 1 day, 35 minutes, and with fares starting at just CLP 45,157, it presents an excellent value for a comfortable ride.
Where are the popular stops in Rome and Prague?
Stops in Rome
- ALargo Guido Mazzoni, 3, 00162 Roma, Italy
- D
Castro Pretorio
Viale Castro Pretorio 76, 00185 Roma, Italy - E
Roma
- F
Anagnina
Via Vincenzo Giudice, 00173 Roma RM, Italy
Stops in Prague
- AKřižíkova 2b, Nové Město, 186 00 Praha-Praha 8, Czech Republic
- BChlumecká, 198 00 Praha 20, Czech Republic
- CTomíčkova 2234, Chodov, 148 00 Praha-Praha 11, Czechia
- DAviatická, 161 08, Praha 6, Czechia
- E
Zličín
Drahoňovského, 163 00 Praha 17, Czech Republic - F300/8 Wilsonova, 110 00 Praha, Czechia
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Frequently asked questions about travelling by bus from Rome to Prague
Please note that timetables, routes, or operator details shown here may be updated or vary at the time of your journey.
How much is the bus ticket from Rome to Prague?
The cheapest coach tickets from Rome to Prague start from CLP 45,157. The average price for this route is around CLP 116,766. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus journey from Rome to Prague?
The average bus journey time from Rome to Prague is 1d , covering a distance of 575 miles. The fastest bus can take you there in 19h 55m and is operated by FlixBus.
Which bus companies service the Rome to Prague route?
What is the earliest and latest departure time for the bus from Rome to Prague?
The earliest bus departs from Rome to Prague at 01:05. And the latest bus departs at 23:50.
What are the CO₂ emissions for the bus trip from Rome to Prague?
A bus journey from Rome to Prague produces an estimated 23.16395 kg of CO₂, making it a highly eco-friendly choice and a mode of travel recommended by Busbud.
Which is the best bus company from Rome to Prague?
According to Busbud customers, the highest-rated bus company on this route is RegioJet, with an average rating of 4.1 out of 5 stars based on 1074 reviews.
Which company has the best Wi-Fi from Rome to Prague?
Based on Busbud reviews, the bus company RegioJet has the best Wi-Fi rating with a score of 3.8.
Which bus company offers the most punctual service from Rome to Prague?
According to Busbud traveller reviews, the most punctual bus company on this route is FlixBus, with a punctuality rating of 4.0 out of 5 stars.
Which bus company has the cleanest buses from Rome to Prague?
According to Busbud traveller reviews, the bus company with the cleanest buses on this route is RegioJet, with a cleanliness rating of 4.4 out of 5 stars.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Rome to Prague was searched and found on 22 Apr 2026 with a price of CLP 60,678To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Rome to Prague as early as possible.
You can expect to pay from CLP 60,678 to CLP 216,894 for a bus ticket from Rome to Prague based on the last 2 days. You can expect to find the cheapest price for the trip at CLP 60,678, which is on 2026-04-22.
