Next train departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Train | Brussels South/Midi Train Station | Hlavní nádraží | Cheapest | ||||
| Train | Brussels South/Midi Train Station | Hlavní nádraží | Fastest | ||||
| Train | Brussels South/Midi Train Station | Hlavní nádraží | No tags | ||||
| Train | Brussels South/Midi Train Station | Hlavní nádraží | No tags | ||||
| Train | Brussels South/Midi Train Station | Hlavní nádraží | No tags | ||||
| Train | Brussels South/Midi Train Station | Hlavní nádraží | No tags |
Last refresh of the prices: Today at 11:37 AM CEST.
Compare 2 ways to go from Brussels to Prague
Among the sustainable travel choices, the Bus stands out as a good way to reach Prague. The journey takes about 18 hours 35 minutes and with fares starting at just ARS 39,809, it presents an excellent value for a comfortable ride.
Where are the popular train stations and stops in Brussels and Prague?
Brussels
- A
Brussels South (Gare du Midi)
Rue de France 85, 1060 Saint-Gilles, Belgium - B
Bruxelles / Brussels Central
Brussel-Centraal, Carrefour de l'Europe, 1000 Bruxelles, Belgium
Prague
- A
Hlavní nádraží
300/8 Wilsonova, 110 00 Praha, Czechia - B
Praha hl.n
Prague Main Railway Station, 120 00 Praha-Praha 2, Czechia - C
PRG Airport
Aviatická, 161 08, Praha 6, Czechia - D
Holešovice
Praha-Holešovice, Partyzánská 1546/26, 170 00 Praha 7-Holešovice, Czechia - E
Florenc
Křižíkova 2b, Nové Město, 186 00 Praha-Praha 8, Czech Republic - F
Černý Most
Chlumecká, 198 00 Praha 20, Czech Republic
Train Companies
Based on 13 reviews, the company was rated 4 stars on Busbud. Travelers were especially satisfied with the ticket access and the departure location but often complained with the wifi. Deutsche Bahn ticket prices on this trip start at ARS 369,935
Frequently asked questions about traveling from Brussels to Prague by train
Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.
How much is the train ticket from Brussels to Prague?
The cheapest train tickets from Brussels to Prague start from ARS 163,665. The average price for this train route is around ARS 227,986. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the train journey from Brussels to Prague?
The average train ride duration from Brussels to Prague is 16h 48m, covering a distance of 446 miles (720 km). The quickest train can get you there in 12h 47m and is operated by Deutsche Bahn.
Which train operators service the Brussels to Prague route?
Several major train operators operate on this route with 1 trains available per day.
What is the earliest and latest departure time for the train from Brussels to Prague?
The earliest train departs from Brussels to Prague at 6:06pm. And the latest train departs at 7:22pm.
Find cheapest prices for trains
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Brussels to Prague was searched and found on Oct 7, 2026 with a price of ARS 107,255To save money and be sure you have the best seat, it's a good idea to buy your train tickets from Brussels to Prague, as early as possible.
You can expect to pay from ARS 107,255 to ARS 876,052 for a train ticket from Brussels to Prague based on the last 2 days. You can expect to find the cheapest price for the trip at ARS 196,198 which is on 2026-10-12.
