Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Bus | Florenc | Brussels South (Gare du Midi) | CheapestFastest |
Last refresh of the prices: Yesterday at 10:25 AM CEST.
Compare 2 ways to travel from Prague to Brussels
Among the sustainable travel choices, the Train stands out as a good way to reach Brussels. The journey takes about 15 hours 22 minutes and with fares starting at just COP 308 372, it presents an excellent value for a comfortable ride.
Where are the popular stops in Prague and Brussels?
Stops in Prague
- AKřižíkova 2b, Nové Město, 186 00 Praha-Praha 8, Czech Republic
- BAviatická, 161 08, Praha 6, Czechia
- C
Zličín
Drahoňovského, 163 00 Praha 17, Czech Republic - DChlumecká, 198 00 Praha 20, Czech Republic
- ETomíčkova 2234, Chodov, 148 00 Praha-Praha 11, Czechia
- F300/8 Wilsonova, 110 00 Praha, Czechia
Stops in Brussels
- ARue de France 85, 1060 Saint-Gilles, Belgium
- BBoulevard Simon Bolivar 7, 1030 Schaerbeek, Belgium
- C
Centrale
Rue de Loxum 5, 1000 Bruxelles, Belgium - DPachecolaan 5, 1000 Brussel, Belgium
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Frequently asked questions about travelling from Prague to Brussels by bus
Please note that timetables, routes, or operator details shown here may be updated or differ at the time of your trip.
How much is the bus ticket from Prague to Brussels?
The cheapest bus tickets from Prague to Brussels start at COP 170 221. The average price for this route is around COP 330 145. Busbud recommends booking your tickets in advance for the best chance of getting the lowest possible price.
How long is the bus journey from Prague to Brussels?
The average bus journey time from Prague to Brussels is 18h 25m, covering a distance of 713 km. The fastest bus gets you there in 12h and is operated by RegioJet.
Which bus companies service the Prague to Brussels route?
Several major bus companies operate on this route with 17 buses available per day, including services from FlixBus, BlaBlaCar Bus, RegioJet.
What is the earliest and latest departure time for the bus from Prague to Brussels?
The earliest bus departs from Prague to Brussels at 01:45. And the latest bus departs at 23:50.
What are the CO₂ emissions for the bus trip from Prague to Brussels?
A bus trip from Prague to Brussels produces an estimated 17.82395 kg of CO₂, making it a highly eco-friendly travel option and Busbud’s recommended way to travel.
What is the best bus company from Prague to Brussels?
According to Busbud customers, the highest-rated bus company on this route is RegioJet, with an average rating of 4.1 out of 5 stars based on 1074 reviews.
Which bus company has the best Wi-Fi from Prague to Brussels?
Based on reviews on Busbud, the bus company RegioJet has the best Wi-Fi rating with a score of 3.8.
Which bus company offers the most punctual service from Prague to Brussels?
According to Busbud traveller reviews, the most punctual bus company on this route is FlixBus, with a punctuality rating of 4.0 out of 5 stars.
Which bus company has the cleanest buses from Prague to Brussels?
According to Busbud traveller reviews, the bus company with the cleanest buses on this route is RegioJet, with a cleanliness rating of 4.4 out of 5 stars.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Prague to Brussels was searched and found on 12 May 2026 with a price of COP 228 829To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Prague to Brussels as early as possible.
You can expect to pay from COP 228 829 to COP 551 805 for a bus ticket from Prague to Brussels based on the last 2 days. You can expect to find the cheapest price for the trip at COP 228 829, which is on 2026-05-12.
What's the cheapest way to go from Prague to Brussels?
The Bus is the cheapest travel choice for this destination
